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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MDH1
All Species:
43.64
Human Site:
S277
Identified Species:
68.57
UniProt:
P40925
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P40925
NP_005908.1
334
36426
S277
G
V
I
S
D
G
N
S
Y
G
V
P
D
D
L
Chimpanzee
Pan troglodytes
XP_001163596
334
36422
S277
G
V
I
S
D
G
N
S
Y
G
V
P
D
D
L
Rhesus Macaque
Macaca mulatta
XP_001084973
344
37589
S287
G
V
I
S
D
G
N
S
Y
G
V
P
D
D
L
Dog
Lupus familis
XP_531844
334
36408
P277
G
I
I
S
D
G
N
P
Y
G
V
P
D
D
L
Cat
Felis silvestris
Mouse
Mus musculus
P14152
334
36493
S277
G
V
I
S
D
G
N
S
Y
G
V
P
D
D
L
Rat
Rattus norvegicus
O88989
334
36465
S277
G
V
I
S
D
G
N
S
Y
G
V
P
D
D
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511259
334
36411
S277
G
V
I
S
D
G
N
S
Y
G
V
P
D
D
L
Chicken
Gallus gallus
Q5ZME2
334
36525
S277
G
V
I
S
D
G
N
S
Y
G
V
P
E
D
L
Frog
Xenopus laevis
Q6PAB3
334
36407
S277
G
V
I
S
D
G
N
S
Y
G
V
P
E
D
L
Zebra Danio
Brachydanio rerio
NP_956263
333
36201
S277
G
V
Y
S
T
G
N
S
Y
G
V
P
E
D
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_609394
337
36040
S276
M
G
V
F
S
D
G
S
Y
D
S
P
K
D
V
Honey Bee
Apis mellifera
XP_394487
333
36140
S276
M
G
V
L
S
D
G
S
Y
G
I
P
K
D
I
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_796283
335
36178
Y277
G
V
Y
N
N
G
S
Y
Y
G
I
P
A
D
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q08062
332
35571
G276
S
M
G
V
Y
S
D
G
S
Y
G
V
P
S
G
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P93819
332
35552
G276
S
M
G
V
Y
S
D
G
S
Y
S
V
P
S
G
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
96.2
95.2
N.A.
96.4
97
N.A.
91.6
90.4
86.8
78.7
N.A.
65.8
63.4
N.A.
68.3
Protein Similarity:
100
100
96.8
98.1
N.A.
99.4
99.6
N.A.
97.5
96.7
94
89.8
N.A.
77.4
77.2
N.A.
82
P-Site Identity:
100
100
100
86.6
N.A.
100
100
N.A.
100
93.3
93.3
80
N.A.
26.6
33.3
N.A.
53.3
P-Site Similarity:
100
100
100
93.3
N.A.
100
100
N.A.
100
100
100
86.6
N.A.
40
53.3
N.A.
80
Percent
Protein Identity:
N.A.
61
N.A.
61.6
N.A.
N.A.
Protein Similarity:
N.A.
73.9
N.A.
75.4
N.A.
N.A.
P-Site Identity:
N.A.
0
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
13.3
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
60
14
14
0
0
7
0
0
47
87
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
20
0
0
% E
% Phe:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
74
14
14
0
0
74
14
14
0
80
7
0
0
0
14
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
7
60
0
0
0
0
0
0
0
14
0
0
0
7
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
14
0
0
% K
% Leu:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
74
% L
% Met:
14
14
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
7
7
0
67
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
7
0
0
0
87
14
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
14
0
0
67
14
14
7
74
14
0
14
0
0
14
0
% S
% Thr:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
67
14
14
0
0
0
0
0
0
67
14
0
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
14
0
14
0
0
7
87
14
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _